123I-IBZM SPECT: reconstruction methodology and results in parkinsonism and dystonia.

Abstract

In 58 patients with Parkinsonism or dystonia striatal dopamine D2 receptors were investigated using 123I-iodobenzamide (123I-IBZM) single-photon emission computed tomography (SPECT). The influence of SPECT reconstruction methodology on semiquantification and the clinical value of 123I-IBZM SPECT were evaluated. Delineation of the striatal uptake and striatum/frontal cortex (ST/FC) ratios were improved by the use of compensation procedures for scatter and attenuation as well as the choice of an adequate filter. Satisfactory results were achieved using a Metz prefilter with a comparatively high order number (i.e. high cut-off and low suppression of higher frequencies via roll-off). Regarding clinical diagnoses it was not possible to differentiate between advanced idiopathic Parkinson's disease (IP) and Parkinsonism of other aetiology (OP) on the basis of 123I-IBZM SPECT. But patients with IP and favourable response to L-Dopa showed significantly higher ST/FC ratios than those with fluctuating response. In patients with dystonia ST/FC ratios were significantly higher compared to patients with IP or OP.

• Authors: G Berding, K F Gratz, H Kolbe, G J Meyer, R Dengler, B O Knoop, H Hundeshagen
• Journal: Nuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 33 Issue 5 Pg. 194-9 (Oct 1994) ISSN: 0029-5566 [Print] Germany
• PMID: 7997377 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Benzamides
• Dopamine Antagonists
• Iodine Radioisotopes
• Pyrrolidines
• Receptors, Dopamine D2
• 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

Topics

• Adult
• Aged
• Aged, 80 and over
• Benzamides (metabolism, therapeutic use)
• Corpus Striatum (diagnostic imaging, metabolism)
• Dopamine Antagonists
• Dystonia (diagnostic imaging, metabolism)
• Frontal Lobe (diagnostic imaging, metabolism)
• Humans
• Iodine Radioisotopes
• Middle Aged
• Parkinson Disease (diagnostic imaging, metabolism)
• Pyrrolidines (metabolism, therapeutic use)
• Receptors, Dopamine D2 (analysis, metabolism)
• Tomography, Emission-Computed, Single-Photon (methods)