Abstract |
The efficacy of hemodilution therapy, to ameliorate cerebral ischemia, is limited by an accompanying decrease in oxygen content. We assessed the effect of hemodilution, with diaspirin cross-linked hemoglobin ( DCLHb), on cerebral blood flow (CBF) and infarct after middle cerebral artery occlusion (MCAo). Rats (n = 36) were alloted to a control group in which hematocrit (Hct) was not manipulated, or reduced with DCLHb to 30% (30/ DCLHb), 16% (16/ DCLHb), or 9% (9/ DCLHb). After MCAo, the brain area with a CBF of 0-10 ml.100g-1.min-1 was determined. This area was decreased in the 30/ DCLHb and 16/ DCLHb groups vs the Control group; and was less in the 9/ DCLHb group vs the other groups. Different rats (n = 49) were hemodiluted with DCLHb or Albumin (Alb): Control, 30/Alb, 30/ DCLHb, 16/ DCLHb, or 9/ DCLHb. After 3-hr of MCAo and 2-hr of reperfusion, infarct area was determined. Brain infarct was less in the 30/ DCLHb and 16/ DCLHb groups vs the Control and 30/Alb groups; and was less in the 9/ DCLHb group vs the other groups. The results of this study support the hypothesis that hemodilution with DCLHb decreases cerebral ischemia in a dose-dependent manner, and in terms of brain ischemia is a more proficient hemodiluting fluid than albumin.
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Authors | D J Cole, R M Schell, J C Drummond |
Journal | Artificial cells, blood substitutes, and immobilization biotechnology
(Artif Cells Blood Substit Immobil Biotechnol)
Vol. 22
Issue 3
Pg. 813-8
( 1994)
ISSN: 1073-1199 [Print] England |
PMID | 7994404
(Publication Type: Journal Article)
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Chemical References |
- Blood Substitutes
- Hemoglobins
- Serum Albumin
- diaspirin-cross-linked hemoglobin
- Aspirin
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Topics |
- Animals
- Aspirin
(analogs & derivatives, pharmacology)
- Blood Substitutes
(pharmacology)
- Blood Volume
- Brain Ischemia
(blood, physiopathology, therapy)
- Cerebral Infarction
(blood, physiopathology, therapy)
- Cerebrovascular Circulation
- Hematocrit
- Hemodilution
- Hemoglobins
(pharmacology)
- Humans
- Rats
- Rats, Inbred SHR
- Serum Albumin
(pharmacology)
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