Abstract |
At least three factors may be responsible for leukemic relapse in patients receiving ABMT: (a) minimal residual disease; (b) leukemic cells reinfused with the graft; and (c) the lack of a graft-versus leukemia effect. Techniques for pharmacological marrow decontamination, clinical result obtained with ABMT and the efficacy of ABMT with mafosfamide purged marrow in patients with acute myelogenous leukemia are reviewed.
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Authors | C Caramatti, L Mangoni, C Carlo-Stella, V Rizzoli |
Journal | Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma
(Acta Biomed Ateneo Parmense)
Vol. 64
Issue 5-6
Pg. 213-20
( 1993)
Italy |
PMID | 7992558
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Antineoplastic Agents
- mafosfamide
- Cyclophosphamide
|
Topics |
- Adjuvants, Immunologic
(pharmacology)
- Antineoplastic Agents
(pharmacology)
- Bone Marrow
(drug effects)
- Bone Marrow Transplantation
(methods)
- Cyclophosphamide
(analogs & derivatives, pharmacology)
- Humans
- Leukemia, Myeloid, Acute
(therapy)
- Recurrence
- Time Factors
- Transplantation, Autologous
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