Filipin test for diagnosis of Niemann-Pick disease type C.

Abstract	The test is based on the reaction of unesterified cholesterol with fluorescent antibiotic filipin giving a strongly fluorescent, stable cholesterol-filipin complex suitable for in situ detection. The test is useful for the evaluation of impaired cholesterol esterification in cultured cells (fibroblasts or others) in Niemann-Pick disease type C.
Authors	J Ledvinová, M Elleder
Journal	Sbornik lekarsky (Sb Lek) Vol. 94 Issue 2 Pg. 137-43 ( 1993) ISSN: 0036-5327 [Print] Czech Republic
PMID	7992006 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Filipin Cholesterol
Topics	Cells, Cultured Child, Preschool Cholesterol (metabolism) Esterification Female Fibroblasts (metabolism) Filipin Humans Infant Male Microscopy, Fluorescence Niemann-Pick Diseases (diagnosis, metabolism) Skin (metabolism)

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