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[Secondary structure of the M2 protein of influenza type A virus and its role in forming resistance to rimantadine and deitiforin].

Abstract
Studies of the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. The influence of aminoacid substitutions in the M2 protein on its secondary structure in the membrane and its role in resistance development was shown.
AuthorsO I Kiselev, V P Mishin, V I Eroshkin, K N Kozeletskaia, E V Usova, V I Rudenko, O N Chupakhin
JournalMolekuliarnaia biologiia (Mol Biol (Mosk)) 1994 Sep-Oct Vol. 28 Issue 5 Pg. 1009-13 ISSN: 0026-8984 [Print] Russia (Federation)
Vernacular TitleVtorichnaia struktura belka M2 virusa grippa tipa A i ego rol' v formirovanii rezistentnosti k remantadinu i deitiforinu.
PMID7990823 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • DNA Primers
  • M-protein, influenza virus
  • M2 protein, Influenza A virus
  • Organic Chemicals
  • Viral Matrix Proteins
  • Rimantadine
  • deitiforin
Topics
  • Amino Acid Sequence
  • Antiviral Agents (pharmacology)
  • Base Sequence
  • DNA Primers
  • Drug Resistance
  • Influenza A virus (chemistry)
  • Molecular Sequence Data
  • Organic Chemicals
  • Protein Structure, Secondary
  • Rimantadine (pharmacology)
  • Viral Matrix Proteins (chemistry, physiology)

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