Abstract |
Studies of the molecular aspects of resistance of influenza virus A to drugs ( rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. The influence of aminoacid substitutions in the M2 protein on its secondary structure in the membrane and its role in resistance development was shown.
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Authors | O I Kiselev, V P Mishin, V I Eroshkin, K N Kozeletskaia, E V Usova, V I Rudenko, O N Chupakhin |
Journal | Molekuliarnaia biologiia
(Mol Biol (Mosk))
1994 Sep-Oct
Vol. 28
Issue 5
Pg. 1009-13
ISSN: 0026-8984 [Print] Russia (Federation) |
Vernacular Title | Vtorichnaia struktura belka M2 virusa grippa tipa A i ego rol' v formirovanii rezistentnosti k remantadinu i deitiforinu. |
PMID | 7990823
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antiviral Agents
- DNA Primers
- M-protein, influenza virus
- M2 protein, Influenza A virus
- Organic Chemicals
- Viral Matrix Proteins
- Rimantadine
- deitiforin
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Topics |
- Amino Acid Sequence
- Antiviral Agents
(pharmacology)
- Base Sequence
- DNA Primers
- Drug Resistance
- Influenza A virus
(chemistry)
- Molecular Sequence Data
- Organic Chemicals
- Protein Structure, Secondary
- Rimantadine
(pharmacology)
- Viral Matrix Proteins
(chemistry, physiology)
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