Effects of CD-832, a dihydropyridine derivative with a nitrate ester moiety on rabbit femoral artery and vein.

Abstract

We investigated the effects of CD-832 ((4R)-(-)-2-(nicotinoyl-amino)ethyl 3-nitroxypropyl 1,4-dihydro-2,6-dimethyl-4,3-nitrophenyl, 3,5-pyridine dicarboxylate), a dihydropyridine derivative with a nitrate ester moiety, on contractile responses in rabbit femoral arteries and veins. CD-832 (10(-8) to 10(-6) M and nifedipine inhibited the 64 mM KCl-induced and 10(-6) M norepinephrine-induced contractions of rabbit femoral arteries, while nitro compounds had no effect on the contractions. CD-832 (10(-8) to 10(-6) M) and nitro compounds inhibited the 10(-6) M norepinephrine-induced contractions in rabbit femoral veins, while other Ca2+ channel antagonists had little effect. The inhibitory effects of CD-832 (10(-7) M) on norepinephrine-induced contractions were antagonized by treatment with methylene blue (10(-5) M). These results indicate that CD-832 potently relaxes venous smooth muscle, and that it may be a useful agent for the treatment of angina pectoris.

• Authors: H Yamaura, N Miyata, K Takahashi, K Tsuchida, S Otomo
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 260 Issue 2-3 Pg. 269-72 (Aug 01 1994) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7988656 (Publication Type: Comparative Study, Journal Article)

Chemical References

• CD 832
• Calcium Channel Blockers
• Niacinamide
• Potassium Chloride
• Nifedipine
• Norepinephrine

Topics

• Animals
• Calcium Channel Blockers (pharmacology)
• Dose-Response Relationship, Drug
• Femoral Artery (drug effects)
• Femoral Vein (drug effects)
• In Vitro Techniques
• Male
• Muscle Contraction (drug effects)
• Muscle, Smooth, Vascular (drug effects)
• Niacinamide (analogs & derivatives, pharmacology)
• Nifedipine (analogs & derivatives, pharmacology)
• Norepinephrine (pharmacology)
• Potassium Chloride (pharmacology)
• Rabbits