Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study.

To investigate the benefit of pentoxifylline in severe experimental pancreatitis.
Prospective, randomized, controlled study.
Experimental animal laboratory in a University hospital.
Forty-two adult male Sprague-Dawley rats.
Acute pancreatitis was induced by supramaximal stimulation with cerulein plus a pressure and volume controlled 10 min intraductal infusion of 10-mM glycodeoxycholic acid. Thirty minutes after pancreatitis was induced, animals were randomized to receive pentoxifylline (60 mg/kg over 2.5 hrs), or saline. All animals received fluid resuscitation with lactated Ringer's solution (8 mL/kg/hr), and surviving animals were killed at 24 hrs.
There was a progressively significant decrease in mean arterial pressure after pancreatitis was induced, with no difference between pentoxifylline-treated rats and controls. Hematocrit increased significantly in both groups at 6 hrs, and returned to baseline values at 24 hrs. Ascites volume and levels of trypsinogen activation peptide in plasma and ascites were similar in both groups. Twenty-four hour mortality was 47% for the pentoxifylline group and 52% for the control group. Histologic scores for necrosis, edema, inflammation, and hemorrhage showed no significant differences between the two groups.
Treatment with pentoxifylline failed to improve outcome in a model of severe acute pancreatitis in the rat.
AuthorsD G Bassi, T Foitzik, D W Rattner, K Lewandrowski, A L Warshaw, C Fernández-del Castillo
JournalCritical care medicine (Crit Care Med) Vol. 22 Issue 12 Pg. 1960-3 (Dec 1994) ISSN: 0090-3493 [Print] UNITED STATES
PMID7988133 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycodeoxycholic Acid
  • Ceruletide
  • Pentoxifylline
  • Acute Disease
  • Analysis of Variance
  • Animals
  • Ceruletide
  • Chi-Square Distribution
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Glycodeoxycholic Acid
  • Male
  • Pancreas (pathology)
  • Pancreatitis (chemically induced, drug therapy, pathology)
  • Pentoxifylline (therapeutic use)
  • Prospective Studies
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

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