HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Failure of pentoxifylline to ameliorate severe acute pancreatitis in the rat: results of a prospective, randomized, controlled study.

AbstractOBJECTIVE:
To investigate the benefit of pentoxifylline in severe experimental pancreatitis.
DESIGN:
Prospective, randomized, controlled study.
SETTING:
Experimental animal laboratory in a University hospital.
SUBJECTS:
Forty-two adult male Sprague-Dawley rats.
INTERVENTIONS:
Acute pancreatitis was induced by supramaximal stimulation with cerulein plus a pressure and volume controlled 10 min intraductal infusion of 10-mM glycodeoxycholic acid. Thirty minutes after pancreatitis was induced, animals were randomized to receive pentoxifylline (60 mg/kg over 2.5 hrs), or saline. All animals received fluid resuscitation with lactated Ringer's solution (8 mL/kg/hr), and surviving animals were killed at 24 hrs.
MEASUREMENTS AND MAIN RESULTS:
There was a progressively significant decrease in mean arterial pressure after pancreatitis was induced, with no difference between pentoxifylline-treated rats and controls. Hematocrit increased significantly in both groups at 6 hrs, and returned to baseline values at 24 hrs. Ascites volume and levels of trypsinogen activation peptide in plasma and ascites were similar in both groups. Twenty-four hour mortality was 47% for the pentoxifylline group and 52% for the control group. Histologic scores for necrosis, edema, inflammation, and hemorrhage showed no significant differences between the two groups.
CONCLUSION:
Treatment with pentoxifylline failed to improve outcome in a model of severe acute pancreatitis in the rat.
AuthorsD G Bassi, T Foitzik, D W Rattner, K Lewandrowski, A L Warshaw, C Fernández-del Castillo
JournalCritical care medicine (Crit Care Med) Vol. 22 Issue 12 Pg. 1960-3 (Dec 1994) ISSN: 0090-3493 [Print] UNITED STATES
PMID7988133 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glycodeoxycholic Acid
  • Ceruletide
  • Pentoxifylline
Topics
  • Acute Disease
  • Analysis of Variance
  • Animals
  • Ceruletide
  • Chi-Square Distribution
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Glycodeoxycholic Acid
  • Male
  • Pancreas (pathology)
  • Pancreatitis (chemically induced, drug therapy, pathology)
  • Pentoxifylline (therapeutic use)
  • Prospective Studies
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: