Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide.

Abstract

The effects of long-term treatment of C57BL/6J (ob/ob) mice with a synthetic carboxylterminal sequence of human growth hormone, hGH 177-191, were investigated. Results indicate that the hGH 177-191 reduced the cumulative body weight gain, and decreased the adipose tissue mass. The lipogenesis in adipose tissues was significantly inhibited by the treatment with hGH 177-191. These findings support the suggestion that hGH 177-191 is the functional domain of hGH for the antilipogenic actions of the intact hormone both in vivo and in vitro. The hGH 177-191 peptide has the potential to be an effective compound for the treatment of human obesity and for the improvement of meat qualities in farm animals.

• Authors: S H Natera, W J Jiang, F M Ng
• Journal: Biochemistry and molecular biology international (Biochem Mol Biol Int) Vol. 33 Issue 5 Pg. 1011-21 (Aug 1994) ISSN: 1039-9712 [Print] England
• PMID: 7987248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• Peptide Fragments
• Triglycerides
• somatotropin (177-191)
• Growth Hormone
• Cholesterol

Topics

• Adipose Tissue (drug effects, metabolism)
• Amino Acid Sequence
• Animals
• Cholesterol (blood)
• Eating
• Female
• Growth Hormone (chemical synthesis, pharmacology)
• Lipids (biosynthesis)
• Male
• Mice
• Mice, Obese
• Molecular Sequence Data
• Obesity (pathology, physiopathology)
• Peptide Fragments (chemical synthesis, pharmacology)
• Sex Factors
• Triglycerides (blood)
• Weight Gain (drug effects)