HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Peroxisome proliferation of hepatocytes in rats by a microbial degradation product of cholic acid, 4-(decahydro-6-methyl-3-oxocyclopenta(f)quinoline-7-yl)valeric acid.

Abstract
Three-week oral administration of 4-(decahydro-6-methyl-3-oxo-cyclopenta(f)quinoline-7-yl)valeric acid (32-1328) in the diet supplemented at concentrations of 0.1% or 0.3% was associated with hepatomegaly and hypotriglyceridemia in male F344 rats. Electron microscopic examination of the liver revealed a remarkable increase of peroxisomes in hepatocytes both in number and size. Biochemically, there were increased activities of peroxisomal marker enzymes including the heat-labile enoyl-CoA hydratase and catalase while the mitochondrial enoyl-CoA hydratase activity was unchanged after feeding of 32-1328. These findings indicate that 32-1328 can exert peroxisome-proliferating activity to rat liver in a manner similar to typical peroxisome proliferators such as clofibrate or di(2-ethylhexyl)phthalate.
AuthorsY Hayashi, K Toyoda, T Imazawa, H Sato, H Okamiya, Y Kurokawa, J Takahashi, T Mogami-Nishimaki, S Hayakawa
JournalExperimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie (Exp Toxicol Pathol) Vol. 46 Issue 2 Pg. 127-32 (Jul 1994) ISSN: 0940-2993 [Print] Germany
PMID7987070 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Quinolines
  • Valerates
  • 4-(decahydromethyl-3-oxo-1H-cyclopentaquinolinyl)valeric acid
Topics
  • Animals
  • Cells, Cultured
  • Liver (drug effects, enzymology, ultrastructure)
  • Male
  • Microbodies (drug effects, enzymology, ultrastructure)
  • Quinolines (pharmacology)
  • Rats
  • Rats, Inbred F344
  • Valerates (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: