Efficacy of 2'-deoxy-2'-fluororibosides against influenza A and B viruses in ferrets.

Abstract

Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. Replication of virus in the lower respiratory tract was also reduced > 100-fold, but three doses were required to prevent replication in the lungs. In ferrets infected with influenza B virus, single-dose treatment (40 mg/kg given intraperitoneally) produced a similar but reduced response in comparison with that in ferrets infected with influenza A virus, indicating that dosing was not optimal for this virus.

• Authors: K J Jakeman, M Tisdale, S Russell, A Leone, C Sweet
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 38 Issue 8 Pg. 1864-7 (Aug 1994) ISSN: 0066-4804 [Print] United States
• PMID: 7986023 (Publication Type: Journal Article)

Chemical References

• 2,6-diaminopurine-2'-fluororiboside
• Antiviral Agents
• Prodrugs
• 2'-deoxy-2'-fluoroguanosine
• Deoxyguanosine
• Adenosine

Topics

• Adenosine (analogs & derivatives, pharmacology)
• Animals
• Antiviral Agents (pharmacology)
• Deoxyguanosine (analogs & derivatives, pharmacology)
• Dose-Response Relationship, Drug
• Ferrets
• Influenza A virus (drug effects)
• Influenza B virus (drug effects)
• Prodrugs (pharmacology)
• Time Factors