MR imaging detection of cerebral metastases with a single injection of high-dose gadoteridol.
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| Abstract |
The utility of a single high-dose (0.3 mmol/kg) injection of gadoteridol, a gadolinium chelate, in the detection of brain metastases on magnetic resonance images was studied. Patients (n = 29) with a high suspicion for brain metastases at clinical examination and by history were imaged on two occasions--separated by more than 24 hours and less than 7 days--with a 0.1 mmol/kg contrast agent dose used for the first study and a 0.3 mmol/kg dose for the second. In patients (n = 15) with confirmed brain metastases by clinical, radiologic, and/or histologic criteria, 40 lesions were detected at the 0.3 mmol/kg dose by a single reader blinded to contrast agent dose, compared with 33 lesions at 0.1 mmol/kg, a 21% increase. Three of 15 patients (20%) demonstrated an increase in the number of lesions detected at the higher dose. Region-of-interest analysis of signal intensity measurements showed that lesion contrast (relative to normal brain) improved from 54% at 0.1 mmol/kg to 92% at 0.3 mmol/kg. A 0.3 mmol/kg dose of gadoteridol, administered in a single injection, permits identification of brain metastases not detected at 0.1 mmol/kg. Such information can influence the choice of therapy.
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| Authors | V M Runge, J W Wells, K L Nelson, P M Linville |
| Journal | Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) 1994 Sep-Oct Vol. 4 Issue 5 Pg. 669-73 ISSN: 1053-1807 [Print] United States |
| PMID | 7981511 (Publication Type: Comparative Study, Journal Article) |
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