Abstract | BACKGROUND AND DESIGN: RESULTS: Topical application of 1% sorbic acid to the forearms of four human volunteers resulted in 250- to 620-fold increases in levels of PGD2 and 15- to 58-fold increases in levels of the metabolite of PGD2, 9 alpha,11 beta-PGF2, in blood drawn from the antecubital vein draining the treated sites. There were no increases in the release of the other vasodilatory prostaglandins, PGE2 or prostacyclin (PGI2). The release of PGD2 in response to topically applied sorbic acid occurred in a dose-dependent manner and was not accompanied by a release of histamine, suggesting that the release of PGD2 was not from the mast cell. CONCLUSIONS: The cutaneous vasodilation that occurs following the administration of sorbic acid is primarily due to a release of PGD2 from a cellular source in the skin.
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Authors | J D Morrow, T A Minton, J A Awad, L J Roberts |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 130
Issue 11
Pg. 1408-12
(Nov 1994)
ISSN: 0003-987X [Print] United States |
PMID | 7979442
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dinoprost
- Aspirin
- Prostaglandin D2
- Sorbic Acid
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Topics |
- Administration, Topical
- Adult
- Aspirin
(pharmacology)
- Dinoprost
(metabolism)
- Dose-Response Relationship, Drug
- Humans
- Middle Aged
- Prostaglandin D2
(metabolism, physiology)
- Skin
(blood supply, metabolism)
- Sorbic Acid
(administration & dosage, pharmacology)
- Vasodilation
(physiology)
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