Evaluation of tumor-associated glycoprotein-72 and CA 125 serum markers in patients with gynecologic diseases.

Abstract

OBJECTIVE:

This study was performed to evaluate the clinical values of tumor-associated glycoprotein-72 serum levels alone or in combination with CA 125 in the diagnosis and monitoring of patients with ovarian cancer.

STUDY DESIGN:

Serum samples from 293 patients, 142 with primary carcinoma and 151 with benign diseases of the genital tract, were evaluated for the presence of CA 125, tumor-associated glycoprotein-72, and carcinoembryonic antigen. All patients underwent surgery for the primary tumor, and stage was defined according to the classification of International Federation of Gynecology and Obstetrics.

RESULTS:

When the measurement of serum tumor-associated glycoprotein-72 is combined with that of CA 125, the sensitivity for the detection of primary ovarian cancer increased from 60% to 73%, with no significant change in specificity, and resulted in a more accurate clinical assessment for detection of residual disease before the second-look procedure. In fact, when both markers were positive, 100% specificity was achieved; conversely, when both markers were negative, no residual disease was found.

CONCLUSION:

These findings suggest that tumor-associated glycoprotein-72 may be considered as a supplementary serum marker for CA 125, providing further clinical information for the diagnosis of primary and recurrent ovarian cancer.

• Authors: F Guadagni, C Marth, A G Zeimet, P Ferroni, A Spila, R Abbolito, M Roselli, J W Greiner, J Schlom
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 171 Issue 5 Pg. 1183-91 (Nov 1994) ISSN: 0002-9378 [Print] United States
• PMID: 7977516 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• CA-125 Antigen
• Carcinoembryonic Antigen
• Glycoproteins
• tumor-associated antigen 72

Topics

• Antigens, Neoplasm (blood)
• Biomarkers, Tumor
• CA-125 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Female
• Genital Diseases, Female (blood)
• Glycoproteins (blood)
• Humans
• Neoplasm, Residual (diagnosis)
• Ovarian Neoplasms (blood, diagnosis, surgery)
• Reoperation
• Sensitivity and Specificity