[A multicenter clinico-epidemiological study of HTLV-I associated uveitis].

Abstract

To elucidate the clinical and epidemiologic features of HTLV-I associated uveitis (HAU), a multicenter case-control study was performed by collaboration of university hospitals throughout Kyushu and Okinawa and two university hospitals in the central metropolitan area. A total of 426 cases of endogenous uveitis were collected and studied between September 1992 and January 1993; about half of the cases were definable for etiology or clinical entity, and the remaining cases were unknown. Assessment of the serum antibodies to HTLV-I revealed that the group of entity-undefined uveitis had a significantly high prevalence of HTLV-I as compared with the age- and sex-matched control subjects, giving supportive evidence for HAU. The titer of serum HTLV-I antibodies was significantly higher in entity-undefined uveitis than in HTLV-carriers. Assuming that a collection of 50 cases of HTLV-I seropositive, etiology-undefined uveitis represents HAU, its clinical features consisted were: (1) middle-aged, otherwise healthy adults developed acute inflammatory uveal disease and presented with visual haze and/or floaters; (2) the disease showed granulomatous or nongranulomatous anterior uveal reactions accompanied by vitreous opacities and retinal vasculitis; (3) the lesions resolved in response to topical or systemic corticosteroids; (4) the visual outcome was usually favorable; (5) nearly half of the cases had recurrent disease; (6) the cases remained systemically unremarkable, except for two cases of HTLV-I associated myelopathy and eight cases of hyper thyroid disease.

• Authors: K Nakao, N Ohba, H Inomata, M Yamamoto, K Ohshima, H Hayashi, S Akiya, K Ibi, M Mochizuki, K Yoshimura
• Journal: Nippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 98 Issue 9 Pg. 858-65 (Sep 1994) ISSN: 0029-0203 [Print] Japan
• PMID: 7976846 (Publication Type: English Abstract, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• HTLV-I Antibodies

Topics

• Adolescent
• Adult
• Aged
• Case-Control Studies
• Child
• Female
• HTLV-I Antibodies (analysis)
• HTLV-I Infections (epidemiology, immunology)
• Humans
• Japan (epidemiology)
• Male
• Middle Aged
• Uveitis (epidemiology, immunology)