Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.

Abstract

Central histaminergic modulation of H1 rather than H2-receptors has been shown to modify epileptic activity. Compounds acting on the HIC- and H3-receptors were tested against chemically-induced seizures in mice. Compounds antagonising the microsomal and nuclear intracellular receptors (HIC) only modified seizures at doses where toxicity was observed. Antagonists of the histamine H3-receptor (thioperamide and burimamide) only potentiated the severity of clonic convulsions induced by picrotoxin, while impromidine (i.c.v.), an antagonist with H2-agonist activity, inhibited leptazol-induced seizures. The H3-agonist, (R)alpha-methylhistamine, potentiated chemically-induced seizures, but at lower doses there was slight inhibition.

• Authors: G Sturman, P Freeman, H M Meade, N A Seeley
• Journal: Agents and actions (Agents Actions) Vol. 41 Spec No Pg. C68-9 (Jun 1994) ISSN: 0065-4299 [Print] Switzerland
• PMID: 7976808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Convulsants
• Histamine Agonists
• Histamine Antagonists
• Histamine H1 Antagonists
• Receptors, Histamine H3
• Picrotoxin
• Pentylenetetrazole

Topics

• Animals
• Anticonvulsants (pharmacology)
• Behavior, Animal (drug effects)
• Convulsants (pharmacology)
• Histamine Agonists
• Histamine Antagonists
• Histamine H1 Antagonists (pharmacology)
• Male
• Mice
• Mice, Neurologic Mutants
• Pentylenetetrazole
• Picrotoxin
• Receptors, Histamine H3 (physiology)
• Seizures (chemically induced)