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Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin.

AbstractBACKGROUND AND OBJECTIVES:
Chancroid is endemic in sub-Saharan Africa and enhances the sexual transmission of the human immunodeficiency virus Type 1 (HIV-1). Azithromycin is an orally absorbed macrolide antibiotic that is active against Haemophilus ducreyi, the causative agent of chancroid, and has pharmacokinetic properties that are suitable for single dosing.
STUDY DESIGN:
In a randomized single-blinded study of 127 men presenting to a referral STD clinic with culture proven chancroid, we compared the efficacy of azithromycin, administered as a single 1 g dose, with erythromycin 500 mg given 4 times daily for 7 days.
RESULTS:
Cure rates were 89% (73 of 82) in the azithromycin group and 91% (41 of 45) in the erythromycin group. A failure to respond to treatment was associated with HIV-1 seropositivity and a lack of circumcision. Both regimens were well tolerated.
CONCLUSIONS:
Azithromycin, given as a single 1 g oral dose, is an effective treatment for chancroid in men, and offers major prescribing advantages over erythromycin.
AuthorsM W Tyndall, E Agoki, F A Plummer, W Malisa, J O Ndinya-Achola, A R Ronald
JournalSexually transmitted diseases (Sex Transm Dis) 1994 Jul-Aug Vol. 21 Issue 4 Pg. 231-4 ISSN: 0148-5717 [Print] United States
PMID7974076 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Erythromycin
  • Azithromycin
Topics
  • AIDS-Related Opportunistic Infections (drug therapy, epidemiology, microbiology)
  • Administration, Oral
  • Adult
  • Azithromycin (administration & dosage)
  • Chancroid (drug therapy, epidemiology, microbiology)
  • Circumcision, Male
  • Erythromycin (administration & dosage)
  • HIV-1
  • Humans
  • Male
  • Referral and Consultation
  • Risk Factors
  • Single-Blind Method
  • Treatment Failure

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