Abstract | BACKGROUND AND OBJECTIVES: Due to the steadily progressive development of resistance to the drugs used for treatment, Neisseria gonorrhoeae remains a medical concern. Trospectomycin sulfate is a 6' propyl analogue of spectinomycin with potent activity against penicillin sensitive and resistant strains of N. gonorrhoeae. GOAL OF THIS STUDY: STUDY DESIGN: Dual-center, randomized comparative trial. RESULTS: CONCLUSIONS:
Trospectomycin sulfate, 250 mg i.m., is effective, and well tolerated. However, for treatment of uncomplicated genital and pharyngeal gonorrhea, it is not as reliable for therapy as other recommended regimens.
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Authors | A M Rompalo, L Colletta, V A Caine, P Linnemeier, T Neumann, E W Hook 3rd, R B Jones |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
1994 Jul-Aug
Vol. 21
Issue 4
Pg. 213-6
ISSN: 0148-5717 [Print] United States |
PMID | 7974072
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- trospectomycin
- Ceftriaxone
- Spectinomycin
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Topics |
- Ceftriaxone
(therapeutic use)
- Confidence Intervals
- Drug Resistance, Microbial
- Female
- Follow-Up Studies
- Gonorrhea
(drug therapy, microbiology)
- Humans
- Injections, Intramuscular
- Male
- Microbial Sensitivity Tests
- Pharyngeal Diseases
(drug therapy, microbiology)
- Spectinomycin
(analogs & derivatives, therapeutic use)
- Treatment Outcome
- Urethral Diseases
(drug therapy, microbiology)
- Uterine Cervical Diseases
(drug therapy, microbiology)
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