Endogenous hypercholecystokininemia, but not aspirin, reduces the gallstone incidence in the hamster model.

Abstract

BACKGROUND:

Studies in humans and rodents indicate that gallstone development may be prevented by inhibiting gallbladder mucus hypersecretion with non-steroidal anti-inflammatory drugs or by preventing stasis of gallbladder bile with administration of cholecystokinin.

METHODS:

The effect of oral aspirin and pancreaticobiliary diversion with endogenous hypercholecystokininemia on crystal and gallstone formation was studied in Syrian golden hamsters fed a lithogenic diet for 8 weeks.

RESULTS:

None of the control animals fed a normal diet developed gallstones or crystals in gallbladder bile. Gallstones developed in 67% of the animals fed a lithogenic diet only. The gallstone prevalence did not differ significantly in animals on a lithogenic diet and a daily aspirin dose of 6 mg/kg (gallstone prevalence, 60%) or 100 mg/kg (gallstone prevalence, 70%), whereas it was significantly lower in animals with endogenous hypercholecystokininemia on a lithogenic diet (gallstone prevalence, 29%). The prevalence of crystals in gallbladder bile did not differ significantly between any of the experimental groups.

CONCLUSIONS:

It is concluded that in hamsters on a lithogenic diet, aspirin does not prevent gallstone formation, whereas endogenous hypercholecystokininemia reduces the prevalence of stones without affecting the occurrence of crystals in gallbladder bile.

• Authors: K Borch, M Chu, E Kullman, B Carlsson, J F Rehfeld
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 29 Issue 8 Pg. 740-3 (Aug 1994) ISSN: 0036-5521 [Print] England
• PMID: 7973435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholecystokinin
• Aspirin

Topics

• Animals
• Aspirin (therapeutic use)
• Biliopancreatic Diversion
• Cholecystokinin (blood, physiology)
• Cholelithiasis (etiology, prevention & control)
• Cricetinae
• Diet
• Male
• Mesocricetus