HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Enteric immunization of mice against influenza with recombinant vaccinia.

Abstract
Intrajejunal administration to mice of a recombinant vaccinia virus containing the influenza virus hemagglutinin gene induced IgA antibody in nasal, gut, and vaginal secretions. It also induced IgG antibody in serum and cell-mediated immunity. The immunization provided significant protection against an influenza virus challenge. This work suggests that enteric-coated recombinant vaccinia could be an orally administered, inexpensive, multivalent, temperature-stable, safe, and effective vaccine for children that could be particularly useful in developing nations, where multiple injections are not easily administered. Oral administration of vaccines should also reduce children's fear of shots at the doctor's office.
AuthorsC A Meitin, B S Bender, P A Small Jr
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 91 Issue 23 Pg. 11187-91 (Nov 08 1994) ISSN: 0027-8424 [Print] United States
PMID7972032 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Viral
  • Antigens, Viral
  • Hemagglutinins, Viral
  • Immunoglobulin A, Secretory
  • Influenza Vaccines
  • Tablets, Enteric-Coated
  • Vaccines, Synthetic
Topics
  • Animals
  • Antibodies, Viral (biosynthesis)
  • Antigens, Viral (administration & dosage)
  • Cytotoxicity, Immunologic
  • Female
  • Hemagglutinins, Viral (immunology)
  • Immunity, Cellular
  • Immunoglobulin A, Secretory (immunology)
  • Influenza Vaccines (administration & dosage, immunology)
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes, Cytotoxic (immunology)
  • Tablets, Enteric-Coated
  • Vaccines, Synthetic
  • Vaccinia virus

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: