Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice.

Abstract	Competitive N-methyl-D-aspartate (NMDA) receptor antagonists, such as CPP and AP-7, dose-dependently enhanced the catalepsy induced by delta 9-tetrahydrocannabinol (THC; 5 mg/kg) in mice, but CPP failed to enhance haloperidol-induced catalepsy. The enhancing effect of CPP on THC-induced catalepsy was dose-dependently blocked by a muscarinic receptor antagonist, scopolamine, and by dopamine D1 and D2 receptor agonists such as apomorphine, SKF 38393 and quinpirole. The effect of CPP was quite opposite to that of the noncompetitive NMDA receptor antagonist MK-801. Therefore, the THC-induced catalepsy model may be useful for distinguishing between both classes of NMDA receptor antagonists.
Authors	H Kinoshita, T Hasegawa, T Kameyama, I Yamamoto, T Nabeshima
Journal	Neuroscience letters (Neurosci Lett) Vol. 174 Issue 1 Pg. 101-4 (Jun 06 1994) ISSN: 0304-3940 [Print] Ireland
PMID	7970141 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amino Acids Anticonvulsants Dopamine Agonists Ergolines Piperazines Receptors, N-Methyl-D-Aspartate Quinpirole 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Dizocilpine Maleate 2-Amino-5-phosphonovalerate Dronabinol 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid Amantadine Scopolamine Haloperidol 2-amino-7-phosphonoheptanoic acid
Topics	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (pharmacology) 2-Amino-5-phosphonovalerate (analogs & derivatives) Amantadine (pharmacology) Amino Acids (pharmacology) Animals Anticonvulsants (pharmacology) Catalepsy (chemically induced) Dizocilpine Maleate (antagonists & inhibitors, pharmacology) Dopamine Agonists (pharmacology) Dose-Response Relationship, Drug Dronabinol (antagonists & inhibitors, pharmacology) Drug Synergism Ergolines (pharmacology) Haloperidol (pharmacology) Male Mice Mice, Inbred Strains Motor Activity (drug effects) Piperazines (pharmacology) Quinpirole Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors) Scopolamine (pharmacology)

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