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The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors.

Abstract
Dopamine D2 receptors were inactivated by N-ethoxycarbonyl-2-ethoxy-1,2,-dihydroxy-quinoline (EEDQ) (6 mg/kg i.p.). The reduction in dopamine receptors was monitored by quantitative receptor autoradiography using [125I]iodosulpiride or [3H]raclopride as radioligands. Pretreatment of male rats with haloperidol (0.3-3 mumol/kg i.p.) produced a dose-related, complete protection against the decrease in [125I]iodosulpiride binding induced by EEDQ in the dorsal and ventral striata and in all cortical areas examined. Raclopride (0.25-10 mumol/kg i.p.) produced the same pattern of effect as haloperidol but had a weaker effect. In contrast, remoxipride (1-40 mumol/kg i.p. or s.c.) only produced a partial protection against the dopamine D2 receptor inactivation by EEDQ. The results in the EEDQ test were related to the potency to block d-amphetamine-induced hyperlocomotion and the ability to induce bar-test catalepsy in the rat. The potencies in the behavioural tests were found to correspond to the in vivo occupancy for dopamine D2 receptors as evaluated by the EEDQ-induced decrease in D2 binding. However, remoxipride differed from both haloperidol and raclopride by showing a much reduced occupancy of dopamine D2 receptors at doses with behaviourally equipotent effects. The results support earlier suggestions that remoxipride in vivo may act on a subpopulation of dopamine D2 receptors.
AuthorsS O Ogren, L Rosén, K Fuxe
JournalNeuroscience (Neuroscience) Vol. 61 Issue 2 Pg. 269-83 (Jul 1994) ISSN: 0306-4522 [Print] United States
PMID7969908 (Publication Type: Journal Article)
Chemical References
  • Quinolines
  • Receptors, Dopamine
  • Salicylamides
  • Remoxipride
  • Raclopride
  • EEDQ
  • Haloperidol
  • Dextroamphetamine
Topics
  • Animals
  • Binding, Competitive
  • Brain (drug effects, metabolism)
  • Catalepsy (chemically induced)
  • Corpus Striatum (drug effects, metabolism)
  • Dextroamphetamine (pharmacology)
  • Dose-Response Relationship, Drug
  • Haloperidol (metabolism, pharmacology)
  • Limbic System (drug effects, metabolism)
  • Male
  • Motor Activity (drug effects)
  • Quinolines (pharmacology)
  • Raclopride
  • Rats
  • Receptors, Dopamine (classification, drug effects)
  • Remoxipride (metabolism, pharmacology)
  • Salicylamides (metabolism, pharmacology)
  • Substantia Nigra (drug effects, metabolism)

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