[Effect of isoptin on toxic and cardiotonic effect of strophanthin K].

Abstract

Two models of heart failure were used in rat experiments to study the effect of isoptin on tolerance to the toxic effect of k-strophanthin. Calcium antagonist-induced changes in the cardiotonic and chronotropic effects of the cardiac glycoside and myocardial oxygen consumption were examined in isolated frog atria with a movable-electrode electron tube and polarography. Isoptin was shown to substantially enhance tolerance to the toxic effect of k-strophanthin and slightly decrease positive inotropic effects of the cardiotonic, by slowing down its development rate. The agent potentiated the negative chronotropic action and lowered myocardial oxygen consumption.

• Authors: S M Lemkina
• Journal: Kardiologiia (Kardiologiia) Vol. 33 Issue 5 Pg. 37-40 ( 1993) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Vliianie izoptina na toksicheskiĭ i kardiotonicheskiĭ éffekty strofantina K.
• PMID: 7967327 (Publication Type: Journal Article)

Chemical References

• Strophanthins
• Verapamil
• strophanthin K

Topics

• Animals
• Cardiac Output, Low (drug therapy, metabolism, physiopathology)
• Drug Interactions
• Electrodes, Implanted
• Heart Atria (metabolism)
• Heart Rate (drug effects)
• Models, Biological
• Myocardium (metabolism)
• Oxygen Consumption (drug effects)
• Ranidae
• Rats
• Rats, Wistar
• Strophanthins (metabolism, pharmacology, therapeutic use)
• Verapamil (metabolism, pharmacology, therapeutic use)