Abstract | OBJECTIVE: DESIGN: A single-blind longitudinal study was performed, lasting 4 months. Patients were treated once a day with placebo, 50 mg losartan, 100 mg losartan and placebo, each for 1 month, in sequence. Measurements were taken at the end of each treatment period. PATIENTS: The study subjects comprised 13 patients with biopsy-proven renal disease, a diastolic blood pressure of > 90 mmHg, creatinine clearance of > 60 ml/min and stable proteinuria of > 2.0 g/day. RESULTS: Mean arterial pressure, measured 4 h after the dose, fell from 113.8 +/- 2.1 mmHg (placebo) to 99.2 +/- 2.4 mmHg (50-mg dose) and 96.5 +/- 2.4 mmHg (100-mg dose). This blood pressure lowering effect was sustained for 24 h 116.3 +/- 2.3 mmHg (placebo) versus 105.5 +/- 1.8 mmHg (50-mg dose) and 103.3 +/- 1.9 mmHg (100-mg dose)]. The glomerular filtration rate remained stable, while the effective renal plasma flow increased by 12.5 +/- 2.9% (100-mg dose). The systemic and renal hemodynamic effects were similar at the 50- and 100-mg doses. Urinary excretion of total protein, albumin and immunoglobulin G decreased dose-dependently by a maximum of +/- 50% (100-mg dose). With the high dose, serum uric acid fell from 0.43 +/- 0.02 mmol/l to 0.39 +/- 0.02 mmol/l, and potassium increased from 4.2 +/- 0.1 to 4.6 +/- 0.1 mmol/l. CONCLUSIONS: The angiotensin II antagonist losartan lowers blood pressure and displays a favorable renal profile in hypertensive patients with renal disease.
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Authors | R T Gansevoort, D de Zeeuw, S Shahinfar, A Redfield, P E de Jong |
Journal | Journal of hypertension. Supplement : official journal of the International Society of Hypertension
(J Hypertens Suppl)
Vol. 12
Issue 2
Pg. S37-42
(Jul 1994)
ISSN: 0952-1178 [Print] England |
PMID | 7965264
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Biphenyl Compounds
- Imidazoles
- Tetrazoles
- Angiotensin II
- Uric Acid
- Losartan
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Topics |
- Albuminuria
(metabolism)
- Angiotensin II
(antagonists & inhibitors)
- Antihypertensive Agents
(therapeutic use)
- Biphenyl Compounds
(therapeutic use)
- Blood Pressure
- Female
- Glomerular Filtration Rate
- Humans
- Hypertension, Renal
(drug therapy, physiopathology)
- Imidazoles
(therapeutic use)
- Longitudinal Studies
- Losartan
- Male
- Proteinuria
(metabolism)
- Renal Circulation
- Single-Blind Method
- Tetrazoles
(therapeutic use)
- Uric Acid
(blood)
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