HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease.

AbstractOBJECTIVE:
To study the effects of the angiotensin II antagonist losartan in hypertensive patients with renal disease.
DESIGN:
A single-blind longitudinal study was performed, lasting 4 months. Patients were treated once a day with placebo, 50 mg losartan, 100 mg losartan and placebo, each for 1 month, in sequence. Measurements were taken at the end of each treatment period.
PATIENTS:
The study subjects comprised 13 patients with biopsy-proven renal disease, a diastolic blood pressure of > 90 mmHg, creatinine clearance of > 60 ml/min and stable proteinuria of > 2.0 g/day.
RESULTS:
Mean arterial pressure, measured 4 h after the dose, fell from 113.8 +/- 2.1 mmHg (placebo) to 99.2 +/- 2.4 mmHg (50-mg dose) and 96.5 +/- 2.4 mmHg (100-mg dose). This blood pressure lowering effect was sustained for 24 h 116.3 +/- 2.3 mmHg (placebo) versus 105.5 +/- 1.8 mmHg (50-mg dose) and 103.3 +/- 1.9 mmHg (100-mg dose)]. The glomerular filtration rate remained stable, while the effective renal plasma flow increased by 12.5 +/- 2.9% (100-mg dose). The systemic and renal hemodynamic effects were similar at the 50- and 100-mg doses. Urinary excretion of total protein, albumin and immunoglobulin G decreased dose-dependently by a maximum of +/- 50% (100-mg dose). With the high dose, serum uric acid fell from 0.43 +/- 0.02 mmol/l to 0.39 +/- 0.02 mmol/l, and potassium increased from 4.2 +/- 0.1 to 4.6 +/- 0.1 mmol/l.
CONCLUSIONS:
The angiotensin II antagonist losartan lowers blood pressure and displays a favorable renal profile in hypertensive patients with renal disease.
AuthorsR T Gansevoort, D de Zeeuw, S Shahinfar, A Redfield, P E de Jong
JournalJournal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 12 Issue 2 Pg. S37-42 (Jul 1994) ISSN: 0952-1178 [Print] England
PMID7965264 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antihypertensive Agents
  • Biphenyl Compounds
  • Imidazoles
  • Tetrazoles
  • Angiotensin II
  • Uric Acid
  • Losartan
Topics
  • Albuminuria (metabolism)
  • Angiotensin II (antagonists & inhibitors)
  • Antihypertensive Agents (therapeutic use)
  • Biphenyl Compounds (therapeutic use)
  • Blood Pressure
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Hypertension, Renal (drug therapy, physiopathology)
  • Imidazoles (therapeutic use)
  • Longitudinal Studies
  • Losartan
  • Male
  • Proteinuria (metabolism)
  • Renal Circulation
  • Single-Blind Method
  • Tetrazoles (therapeutic use)
  • Uric Acid (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: