Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: Compared with the control group, dogs in both the captopril and metoprolol groups had reduced left ventricular mass as measured by magnetic resonance imaging (-8.1 +/- 3.8 vs. 1.7 +/- 2.8 g, p = 0.003 and -9.6 +/- 5.6 vs. 1.7 +/- 2.8 g, p = 0.001), respectively. Captopril and metoprolol also produced a reduction in left ventricular end-diastolic volume (-7.6 +/- 6.0 and -6.0 +/- 5.8 ml, respectively) compared with the control value (-1.6 +/- 3.8 ml) (p = 0.14 [NS]). Both agents reduced mean arterial pressure but had disparate effects on pulmonary wedge pressure and right atrial pressure. There was no significant correlation between change in ventricular mass or volume and change in any measured hemodynamic or neurohormonal variable. CONCLUSIONS: These data suggest that pharmacologic intervention with angiotensin-converting enzyme inhibition or beta- adrenoceptor blockade can result in regression of established ventricular remodeling. The mechanism of this response will require further study, but these data did not support a close association between regression of remodeling and hemodynamic unloading of the ventricle or systemic neuroendocrine factors.
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Authors | K M McDonald, T Rector, P F Carlyle, G S Francis, J N Cohn |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 24
Issue 7
Pg. 1762-8
(Dec 1994)
ISSN: 0735-1097 [Print] United States |
PMID | 7963126
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Animals
- Captopril
(pharmacology, therapeutic use)
- Dogs
- Hemodynamics
(drug effects)
- Hypertrophy, Left Ventricular
(drug therapy, pathology, physiopathology)
- Magnetic Resonance Imaging
- Metoprolol
(pharmacology, therapeutic use)
- Myocardial Infarction
(complications, physiopathology)
- Random Allocation
- Stroke Volume
(drug effects)
- Ventricular Function
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