Adinazolam sustained-release treatment of panic disorder: a double-blind study.

Abstract

Two hundred six outpatients with panic disorder and agoraphobia were randomly assigned to receive 4 weeks of treatment with placebo or sustained-release adinazolam under double-blind conditions. Eighty-eight percent of patients receiving drug and 85% of patients receiving placebo remained in the study at week 4. This report describes the "intent-to-treat" analysis of 202 patients who made at least one follow-up visit after randomization at baseline. On the basis of the Clinical Global Impressions-Improvement Scale, 69.7% of the adinazolam-treated patients were much or very much improved compared with 39.6% of the placebo-treated patients at week 4 or end-point (p = 0.0001). At week 4, panic attacks were completely blocked in 57.1% of adinazolam-treated patients and in 39.2% of the placebo-treated patients (p = 0.009). Adinazolam sustained-release treatment was statistically more effective than placebo treatment on measures of global improvement, number of panic attacks, SCL-90 phobia severity, main phobia severity, and anticipatory and general anxiety. No drug-placebo differences were found for overall self-rated phobia severity, unexpected or situational panic attacks, or for work, family, or social disability.

• Authors: J R Davidson, B Beitman, J H Greist, R J Maddock, C P Lewis, A Q Sheridan, C Carter, K R Krishnan, M R Liebowitz, D G Haack
• Journal: Journal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 14 Issue 4 Pg. 255-63 (Aug 1994) ISSN: 0271-0749 [Print] United States
• PMID: 7962681 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Anxiety Agents
• Antidepressive Agents
• Delayed-Action Preparations
• Benzodiazepines
• adinazolam

Topics

• Adult
• Agoraphobia (drug therapy, psychology)
• Anti-Anxiety Agents
• Antidepressive Agents (administration & dosage, adverse effects)
• Benzodiazepines (administration & dosage, adverse effects)
• Delayed-Action Preparations
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Panic Disorder (drug therapy, psychology)
• Personality Assessment (statistics & numerical data)
• Personality Inventory (statistics & numerical data)
• Psychometrics
• Treatment Outcome