Increased cAMP levels in human hair follicles due to local treatment with trichoriboside.

Abstract

Local therapy with trichoriboside and trichosaccharide, which have been found to be beneficial for scalp hair maintenance in adult males affected by androgenic alopecia, was found to increase cAMP levels in human scalp hair follicles. The increase was significant in men affected by androgenic alopecia, whereas it was not significant in unaffected control men. Trichoriboside showed a greater activity than trichosaccharide, and such activity was accompanied by a significant concomitant reduction of ATP in the hair.

• Authors: G Gazzani, S Roncoroni, M Corsi, M Falchi, M E Ferrero
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 16 Issue 2 Pg. 73-7 ( 1994) ISSN: 0250-0868 [Print] Switzerland
• PMID: 7960503 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Polydeoxyribonucleotides
• Polysaccharides
• trichoriboside
• trichosaccharide
• Adenosine Triphosphate
• Cyclic AMP

Topics

• Adenosine Triphosphate (analysis, metabolism)
• Administration, Topical
• Adult
• Alopecia (drug therapy)
• Cyclic AMP (analysis, metabolism)
• Hair (chemistry, metabolism)
• Humans
• Male
• Middle Aged
• Polydeoxyribonucleotides (administration & dosage, pharmacology, therapeutic use)
• Polysaccharides (administration & dosage, pharmacology, therapeutic use)