Food-induced increase in bioavailability of 5-methoxypsoralen.

Abstract

5-Methoxypsoralen (5-MOP) in combination with ultraviolet light exposure is used for the treatment of psoriasis. The effect of food on the pharmacokinetics of 5-MOP was evaluated in a randomized, crossover study in nine healthy subjects. Each subject received the tablets with a standardized breakfast or under fasting conditions. The food had a dramatic effect on the bioavailability of 5-MOP. Five of the subjects showed no measurable quantities (detection limit of the analytical technique 1 ng.ml-1) of 5-MOP when the drug was given under fasting conditions. However, plasma peak concentration within the range 37-144 ng.ml-1 (median 102 ng.ml-1) was measured when the drug was taken with food. The time for the plasma peak concentration was within the range 2.0-5.1 h (median 3.0 h) under non-fasting conditions. The elimination half-life was within the range 1.4-2.7 h (median 1.9 h). We conclude that it is imperative that 5-MOP tablets are administered together with food.

• Authors: H Ehrsson, I Wallin, A M Ros, S Eksborg, M Berg
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 46 Issue 4 Pg. 375-7 ( 1994) ISSN: 0031-6970 [Print] Germany
• PMID: 7957526 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Tablets
• 5-Methoxypsoralen
• Methoxsalen

Topics

• 5-Methoxypsoralen
• Adult
• Biological Availability
• Cross-Over Studies
• Fasting (blood)
• Female
• Food
• Half-Life
• Humans
• Male
• Methoxsalen (analogs & derivatives, pharmacokinetics)
• Middle Aged
• Tablets