Role of the measurement of serum procollagen type III N-terminal peptide in the evaluation of liver diseases.

Abstract

Serum N-terminal procollagen-III peptide (PIIIP) was measured in 151 patients with diverse liver diseases together with other clinical and laboratory data. Patients with cirrhosis had higher serum PIIIP than those without cirrhosis (P < 0.0001). Significant associations were found between PIIIP and many data characteristic of liver diseases, including alcohol markers. Serum PIIIP was also associated with portal hypertension (P = 0.0001), although such association was probably due to the fact that most patients with portal hypertension were cirrhotic patients. The predictive values of PIIIP in portal hypertension were too low to be clinically useful. No one single factor could be identified as responsible for the increase in PIIIP and the data suggest that the mechanism is multifactorial. Measurement of serum PIIIP has a limited clinical value in the evaluation of patients with diverse liver diseases.

• Authors: J Collazos, F Díaz
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 227 Issue 1-2 Pg. 37-43 (Jun 1994) ISSN: 0009-8981 [Print] Netherlands
• PMID: 7955420 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Peptide Fragments
• Procollagen
• procollagen Type III-N-terminal peptide

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Female
• Humans
• Liver Cirrhosis (blood, diagnosis)
• Liver Diseases (blood, diagnosis)
• Male
• Middle Aged
• Peptide Fragments (blood)
• Procollagen (blood)
• Sensitivity and Specificity