Abstract | BACKGROUND: Children with malignant diseases are frequently given high dose chemotherapy plus autologous bone marrow transplants. Infectious complications can lead to morbidity and mortality in this type of treatment. This study was designed to determine whether immunoglobulin deficiency is an additional risk factor for infections. PATIENTS AND METHODS: CONCLUSIONS: Immune replacement during bone marrow transplantation may be indicated in children at risk of Ig deficiency. Fifty percent of the children with solid tumors treated in our institution were at risk of this deficiency.
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Authors | J Grill, M C Robert-Le Deley, D Valteau-Couanet, L Brugières, C Kalifa, O Hartmann |
Journal | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
(Arch Pediatr)
Vol. 1
Issue 5
Pg. 463-9
(May 1994)
ISSN: 0929-693X [Print] France |
Vernacular Title | Immunité humorale et infections pendant l'autogreffe de moelle osseuse chez l'enfant: étude de 127 patients greffés successivement dans un même centre. |
PMID | 7951830
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Antibody Formation
- Bone Marrow Transplantation
(immunology)
- Child
- Child, Preschool
- Humans
- Immunocompromised Host
- Immunoglobulins
(analysis)
- Infant
- Neoplasms
(drug therapy, therapy)
- Sepsis
(epidemiology, etiology, immunology)
- Transplantation Immunology
- Transplantation, Autologous
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