HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A case of ectopic ACTH syndrome associated with Zollinger-Ellison syndrome: long-term survival with chemical adrenalectomy.

Abstract
The female patient in this report was suffering from a pancreatic islet cell tumor which exhibited ectopic ACTH syndrome associated with Zollinger-Ellison syndrome. When this combined syndrome was diagnosed, there were already multiple metastasis to the liver. Zollinger-Ellison syndrome was treated with a histamine-H2-receptor blocker, and ectopic ACTH syndrome was controlled with trilostane, metyrapone and o,p'-DDD. She survived more than 6 years after the diagnosis, mostly as an outpatient. During treatment she became cachexic. After she died, an autopsy was done. Immunohistochemical staining established that tumor cells contained ACTH- and gastrin-like immunoreactivity. Our treatment suggested the efficacy of chemical adrenalectomy in managing ectopic ACTH syndrome associated with Zollinger-Ellison syndrome.
AuthorsH Ishido, N Yamashita, M Kitaoka, Y Tanaka, E Ogata
JournalEndocrine journal (Endocr J) Vol. 41 Issue 2 Pg. 171-6 (Apr 1994) ISSN: 0918-8959 [Print] Japan
PMID7951565 (Publication Type: Case Reports, Journal Article)
Topics
  • ACTH Syndrome, Ectopic (etiology, mortality, surgery)
  • Adrenalectomy (methods)
  • Carcinoma, Islet Cell (complications, mortality, secondary, surgery)
  • Female
  • Humans
  • Middle Aged
  • Pancreatic Neoplasms (complications, mortality, surgery)
  • Survival Rate
  • Time Factors
  • Zollinger-Ellison Syndrome (etiology, mortality, surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: