[The new anti-alcohol preparation medikhronal: changes in the level of ethanol, acetaldehyde and monoamines during the treatment of alcoholism patients].

Abstract

Treating patients with stage-II alcoholism with medichronal and unithiol sharply decreases blood levels of alcohol and acetaldehyde. Medichronal restores the decreased level of norepinephrine excretion in 25% of patients and the increased level of epinephrine in 43%. The high baseline concentration of serotonin dropped in 41%, however, its level remained higher than in the controls. There was a negative correlation between the changes of ethanol concentrations and the excretion of norepinephrine. There was a direct dependence between the changes in the norepinephrine/epinephrine ratio and the serotonin concentration.

• Authors: G Kh Bozhko, P V Voloshin, T P Boĭko, L S Kostiukovskaia, Iu G Kholodnyĭ, L M Markozova, Z N Bolotova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1994 Jul-Aug Vol. 57 Issue 4 Pg. 64-6 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Novyĭ antialkogol'nyĭ preparat medikhronal: izmenenie soderzhaniia étanola, atsetal'degida i monoaminov pri lechenii bol'nykh alkogolizmom.
• PMID: 7950793 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Alcohol Deterrents
• Biogenic Monoamines
• Drug Combinations
• Formates
• medikhronal
• Ethanol
• Acetaldehyde
• Glucose
• Glycine

Topics

• Acetaldehyde (blood)
• Adult
• Alcohol Deterrents (therapeutic use)
• Alcoholism (blood, drug therapy, urine)
• Biogenic Monoamines (metabolism)
• Drug Combinations
• Drug Evaluation
• Ethanol (blood)
• Formates (therapeutic use)
• Glucose (therapeutic use)
• Glycine (therapeutic use)
• Humans
• Male
• Time Factors