Abstract |
The purpose of this study was to determine imipenem concentrations in vitreous humor of non-infected human eyes. Ten patients undergoing vitrectomy were infused with a single dose of either 0.5g (5 patients) or 1g (5 patients) of imipenem. Vitreous humor was withdrawn 2 or 4 hours after the end of the infusion. Results differed in relation to the dose. After 0.5g, vitreous levels were stable (approximately 0.20 mg/l), but after 1g they were significantly higher (approximately 2 mg/l). These levels were above the minimum inhibitory concentration of imipenem for 90% (MIC 90) of the main species responsible for endophthalmitis.
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Authors | J P Adenis, M Mounier, J L Salomon, F Denis |
Journal | European journal of ophthalmology
(Eur J Ophthalmol)
1994 Apr-Jun
Vol. 4
Issue 2
Pg. 115-7
ISSN: 1120-6721 [Print] United States |
PMID | 7950335
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Aged
- Humans
- Imipenem
(administration & dosage, pharmacokinetics)
- Infusions, Intravenous
- Vitrectomy
- Vitreous Body
(metabolism)
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