20 alpha-hydroxysteroid dehydrogenase activity in canine spontaneous neoplasms.

Abstract

20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) activities in 57 neoplastic tissues surgically removed from dogs were measured. Forty-eight of 57 tumor samples were shown to possess 20 alpha-HSD activity. These tissues were histopathologically classified into 22 benign and 26 malignant tumors. Among these tumors, mixed tumor types demonstrated the higher 20 alpha-HSD activity than epithelial and non-epithelial types, and malignant tumors of each tissue type showed slightly but not significantly higher 20 alpha-HSD activities comparing with the corresponding benign ones. Comparing with the activity of normal tissues examined, the corresponding tumor tissues showed significantly higher 20 alpha-HSD activities. Thus, 20 alpha-HSD activity was found in neoplastic tissues at a considerable high rate and the activity seemed to be higher in pathologically malignant tumors.

• Authors: N M Tanaka, K Shiota, K Noda, S Kokubo, T Kadosawa, R Nishimura, M Takahashi, N Sasaki
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 56 Issue 3 Pg. 581-3 (Jun 1994) ISSN: 0916-7250 [Print] Japan
• PMID: 7948398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 20-Hydroxysteroid Dehydrogenases
• 20-alpha-Hydroxysteroid Dehydrogenase

Topics

• 20-Hydroxysteroid Dehydrogenases (analysis)
• 20-alpha-Hydroxysteroid Dehydrogenase
• Animals
• Anus Neoplasms (enzymology, pathology, veterinary)
• Dog Diseases
• Dogs
• Female
• Liver Neoplasms (enzymology, pathology, veterinary)
• Male
• Mammary Neoplasms, Animal (enzymology, pathology)
• Neoplasms (enzymology, pathology, veterinary)
• Ovarian Neoplasms (enzymology, pathology, veterinary)
• Skin Neoplasms (enzymology, pathology, veterinary)
• Testicular Neoplasms (enzymology, pathology, veterinary)