Abstract |
The opioid antagonist naltrexone was administered to 8 adults with severe or profound mental retardation and extensive histories of self-injurious behavior. Five-minute behavioral samples were observed randomly out of every hour from 8 a.m. through 3 p.m., Monday through Friday, for four 2-week phases (baseline, placebo, 50 mg, and 100 mg). During naltrexone administration, there were fewer days with frequent head-banging and self-biting, whereas there were more days on which blows to the head or self-biting were infrequent. Self-injurious participants slept 1.38 hours less per night during baseline, which was unaffected by naltrexone.
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Authors | T Thompson, T Hackenberg, D Cerutti, D Baker, S Axtell |
Journal | American journal of mental retardation : AJMR
(Am J Ment Retard)
Vol. 99
Issue 1
Pg. 85-102
(Jul 1994)
ISSN: 0895-8017 [Print] United States |
PMID | 7946257
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptors, Opioid
- Naltrexone
- Clonidine
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Topics |
- Adult
- Clonidine
(adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Intellectual Disability
(drug therapy, psychology)
- Liver Function Tests
- Male
- Naltrexone
(adverse effects, therapeutic use)
- Receptors, Opioid
(drug effects)
- Self-Injurious Behavior
(drug therapy, psychology)
- Social Environment
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