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Opioid antagonist effects on self-injury in adults with mental retardation: response form and location as determinants of medication effects.

Abstract
The opioid antagonist naltrexone was administered to 8 adults with severe or profound mental retardation and extensive histories of self-injurious behavior. Five-minute behavioral samples were observed randomly out of every hour from 8 a.m. through 3 p.m., Monday through Friday, for four 2-week phases (baseline, placebo, 50 mg, and 100 mg). During naltrexone administration, there were fewer days with frequent head-banging and self-biting, whereas there were more days on which blows to the head or self-biting were infrequent. Self-injurious participants slept 1.38 hours less per night during baseline, which was unaffected by naltrexone.
AuthorsT Thompson, T Hackenberg, D Cerutti, D Baker, S Axtell
JournalAmerican journal of mental retardation : AJMR (Am J Ment Retard) Vol. 99 Issue 1 Pg. 85-102 (Jul 1994) ISSN: 0895-8017 [Print] United States
PMID7946257 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Receptors, Opioid
  • Naltrexone
  • Clonidine
Topics
  • Adult
  • Clonidine (adverse effects, therapeutic use)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Intellectual Disability (drug therapy, psychology)
  • Liver Function Tests
  • Male
  • Naltrexone (adverse effects, therapeutic use)
  • Receptors, Opioid (drug effects)
  • Self-Injurious Behavior (drug therapy, psychology)
  • Social Environment

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