Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus.

Abstract

CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.

• Authors: R S Ostrow, S Coughlin, R C McGlennen, Z Liu, D Zelterman, A J Faras
• Journal: Antiviral research (Antiviral Res) Vol. 24 Issue 1 Pg. 27-35 (May 1994) ISSN: 0166-3542 [Print] Netherlands
• PMID: 7944311 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Organometallic Compounds
• CTC 96

Topics

• Administration, Topical
• Animals
• Antiviral Agents (toxicity)
• Cottontail rabbit papillomavirus
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Organometallic Compounds (toxicity)
• Papillomavirus Infections (drug therapy, virology)
• Rabbits
• Tumor Virus Infections (drug therapy, virology)
• Warts (drug therapy, pathology, virology)