HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Detection of circulating antigens in the diagnosis of acute toxoplasmosis.

Abstract
Using an enzyme-linked immunosorbent assay, we have found circulating antigens of Toxoplasma gondii in three models of murine toxoplasmosis: mice infected with trophozoites of the RH strain (acute toxoplasmosis), the Beverley strain (subacute toxoplasmosis), and the T626 strain (chronic toxoplasmosis). Circulating antigens were detected 48 hr after infection in the mice infected with the RH strain, and all mice had antigenemia by the fourth day. In those infected with the Beverley strain, circulating antigens were detected from the second day after inoculation until the end of the study, with a peak (71% of the infected mice) on day 10. Of those infected with the T626 strain, 40% had antigenemia at 13 days after infection. The detection of circulating antigens in serum is directly related to the presence of toxoplasmosis in the acute phase in the three models studied and, therefore, may prove very useful in the rapid diagnosis of this disease.
AuthorsM V Acebes, B Diez, J A Garcia-Rodriguez, P Viens, R Cisterna
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 51 Issue 4 Pg. 506-11 (Oct 1994) ISSN: 0002-9637 [Print] United States
PMID7943580 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Immunoglobulin G
Topics
  • Acute Disease
  • Animals
  • Antibodies, Protozoan (blood)
  • Antigens, Protozoan (blood)
  • Brain (parasitology)
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Immunoglobulin G (blood)
  • Mice
  • Rabbits
  • Sensitivity and Specificity
  • Toxoplasma (immunology, isolation & purification)
  • Toxoplasmosis, Animal (diagnosis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: