A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin.
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| Abstract |
Hemorheologic factors probably play a role in the pathogenesis and prognosis of retinal vein occlusion. Accordingly, we designed a prospective, randomized, double-masked study to evaluate the effect of troxerutin, a rheologic drug, on retinal vein occlusion. Fifty-three patients were included, 27 with central retinal vein occlusion and 26 with branch retinal vein occlusion. They were randomly assigned for treatment with either troxerutin or a placebo. All subjects were similar in age, gender, associated diseases, hemorheologic values, and clinical severity of the retinal vein occlusion. At the end of follow-up, members of the troxerutin-treated group, as compared with the placebo group, showed significant improvement in visual acuity (P = .03), macular threshold (P = .01), retinal circulation times (P = .04), and macular edema (P = .05). Furthermore, they had diminished progression of ischemia (P = .05) and decreased red blood cell aggregability (P = .006) when compared with the controls. These encouraging preliminary results obtained with a rheologic treatment attest to the pathogenic role of blood viscosity in retinal vein occlusion and suggest that a large-scale randomized study should be conducted.
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| Authors | A Glacet-Bernard, G Coscas, A Chabanel, A Zourdani, F Lelong, M M Samama |
| Journal | American journal of ophthalmology (Am J Ophthalmol) Vol. 118 Issue 4 Pg. 421-9 (Oct 15 1994) ISSN: 0002-9394 [Print] United States |
| PMID | 7943118 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial) |
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