[The relationship of the therapeutic efficacy of immunoglobulin against tick-borne encephalitis to the specific activity of the preparation and the times of its administration].

Abstract

A controlled clinical trial included 115 patients with meningeal and focal tick-borne encephalitis, 38 of them received nonspecific treatment alone, 77 were given adjuvant intramuscular immunoglobulin against tick-borne encephalitis. The latter are shown to improve much more rapidly than patients treated only symptomatically. When calculating adequate immunoglobulin doses, it is necessary to take in consideration not only the amount of the compound, but also the concentration of the specific antibodies. The authors propose treatment schemes for patients with meningeal and focal tick-borne encephalitis.

• Authors: L A Vereta, T A Zakharycheva, V I Aleksandrov, V V Skupchenko, S P Nikolaeva
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 94 Issue 2 Pg. 68-70 ( 1994) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Sviaz' lechebnoĭ éffektivnosti immunoglobulina protiv kleshchevogo éntsefalita so spetsificheskoĭ aktivnost'iu preparata i srokami ego vvedeniia.
• PMID: 7941897 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Immunoglobulins

Topics

• Acute Disease
• Antibodies, Viral (administration & dosage, immunology)
• Antibody Specificity
• Dose-Response Relationship, Immunologic
• Encephalitis Viruses, Tick-Borne (immunology)
• Encephalitis, Tick-Borne (therapy)
• Humans
• Immunoglobulins (administration & dosage, immunology)
• Injections, Intramuscular
• Meningoencephalitis (therapy)
• Remission Induction
• Time Factors