[A trial of the long-term use of a low-protein diet and ketosteril in chronic kidney failure].

Abstract

Ten CRF patients (mean glomerular filtration rate 10.1 ml/min) were put on low-protein diet (0.3 g/kg protein daily) supplemented with ketosteryl (10-12 pills daily). During 3 out of 6-34 months of the diet azotemia declined: creatinine, blood urea nitrogen, uric acid, phosphorus concentrations diminished by 5%, 12%, 10% and 17%, respectively. Further accumulation of nitrogen residues slowed down. Monthly increment of serum creatinine and hemoglobin loss rate reduced 2-fold (from 0.23 to 0.117 mg% month and from 0.16 to 0.08 g% month, respectively). Protein deficiency did not occur as serum albumin and body mass remained the same, whereas urea nitrogen/creatinine ratio showed a 35% decrease. It is concluded that rigorous low-protein diet combined with keto-analogues of essential amino acids is able to abate uremia and inhibit CRF augmentation.

• Authors: N L Lifshin, A Iu Nikolaev, V M Ermolenko
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 66 Issue 6 Pg. 51-5 ( 1994) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Opyt dlitel'nogo primeneniia malobelkovoĭ diety i ketosterila pri khronicheskoĭ pochechnoĭ nedostatochnosti.
• PMID: 7940369 (Publication Type: Case Reports, Clinical Trial, English Abstract, Journal Article)

Chemical References

• Amino Acids, Essential
• Tablets
• ketosteril

Topics

• Adult
• Amino Acids, Essential (administration & dosage)
• Combined Modality Therapy
• Diet, Protein-Restricted (methods)
• Female
• Humans
• Kidney Failure, Chronic (diet therapy, metabolism)
• Male
• Middle Aged
• Renal Dialysis
• Tablets
• Time Factors
• Uremia (diet therapy, metabolism)