[Plasmapheresis in the combined therapy of progressive forms of glomerulonephritis].

Abstract

29 patients aged 6-16 with glomerulonephritis lasting 4-5 years received multimodality treatment with plasmapheresis as a component. The majority of the patients suffered from primary glomerulonephritis in mesangio- or membrano-proliferative morphological variants. Previous long-term conventional therapy (prednisolone, cytostatics, anticoagulants and antiaggregation drugs) failed. The test course comprised 1-3 plasmapheresis sessions (centrifuge method on [symbol: see text] apparatus), cyclophosphamide or maintenance methyl-prednisolone pulse therapy, heparin and curantil. One-third of the patients achieved remission lasting from 5 months to 3 years, in the other one-third the improvement was as short as 2-4 weeks, and the last one-third appeared non-responders. Improvement of clinical indices occurred in parallel with trends to reduction in the levels of CIC, IgG, B-lymphocytes, T-helpers, inhibition of lymphocyte succinate dehydrogenase activity, better phagocytosis. No complications which may prohibit plasmapheresis use in glomerulonephritis were observed. Adjuvant plasmapheresis use in glomerulonephritis treatment needs further studies.

• Authors: E S Moskaleva, M S Ignatova, V A Korneeva, Iu V Muromtsev, E I Tsvetkova, N M Parubinovskaia, E A Kharina, O V Katysheva, A V Krivonos
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 66 Issue 6 Pg. 42-5 ( 1994) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Plazmaferez v kompleksnoĭ terapii progressiruiushchikh form glomerulonefrita.
• PMID: 7940367 (Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)

Topics

• Adolescent
• Antibody Formation
• Child
• Chronic Disease
• Combined Modality Therapy
• Drug Therapy, Combination
• Evaluation Studies as Topic
• Glomerulonephritis (immunology, therapy)
• Humans
• Immunity, Cellular
• Plasmapheresis (instrumentation)
• Remission Induction
• Time Factors