| Abstract | 29 patients aged 6-16 with glomerulonephritis lasting 4-5 years received multimodality treatment with plasmapheresis as a component. The majority of the patients suffered from primary glomerulonephritis in mesangio- or membrano-proliferative morphological variants. Previous long-term conventional therapy (prednisolone, cytostatics, anticoagulants and antiaggregation drugs) failed. The test course comprised 1-3 plasmapheresis sessions (centrifuge method on [symbol: see text] apparatus), cyclophosphamide or maintenance methyl-prednisolone pulse therapy, heparin and curantil. One-third of the patients achieved remission lasting from 5 months to 3 years, in the other one-third the improvement was as short as 2-4 weeks, and the last one-third appeared non-responders. Improvement of clinical indices occurred in parallel with trends to reduction in the levels of CIC, IgG, B-lymphocytes, T-helpers, inhibition of lymphocyte succinate dehydrogenase activity, better phagocytosis. No complications which may prohibit plasmapheresis use in glomerulonephritis were observed. Adjuvant plasmapheresis use in glomerulonephritis treatment needs further studies. |
| Authors | E S Moskaleva, M S Ignatova, V A Korneeva, Iu V Muromtsev, E I Tsvetkova, N M Parubinovskaia, E A Kharina, O V Katysheva, A V Krivonos |
| Journal | Terapevticheskiĭ arkhiv
(Ter Arkh)
Vol. 66
Issue 6
Pg. 42-5
( 1994)
ISSN: 0040-3660 RUSSIA |
| Vernacular Title | Plazmaferez v kompleksnoĭ terapii progressiruiushchikh form glomerulonefrita. |
| PMID | 7940367
(Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)
|
| Topics |
- Adolescent
- Antibody Formation
- Child
- Chronic Disease
- Combined Modality Therapy
- Drug Therapy, Combination
- Evaluation Studies as Topic
- Glomerulonephritis
(immunology, therapy)
- Humans
- Immunity, Cellular
- Plasmapheresis
(instrumentation)
- Remission Induction
- Time Factors
|
