Abstract |
PS-15 is a novel biguanide folate antagonist that is metabolized in vivo to WR99210, a metabolite that is extremely active in vitro against multi- drug resistant strains of Plasmodium falciparum. When PS-15 was administered in combination with sulfamethoxazole to healthy Saimiri sciureus monkeys, the serum antimalarial activity was considerably greater than that observed in monkeys that received PS-15 alone. Further studies should be carried out to determine the value of PS-15/ sulfonamide combinations in the treatment of human malaria infections and in preventing the emergence of drug-resistant parasites.
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Authors | A E Yeo, K H Rieckmann |
Journal | Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)
(Trop Med Parasitol)
Vol. 45
Issue 2
Pg. 136-7
(Jun 1994)
ISSN: 0177-2392 [Print] Germany |
PMID | 7939165
(Publication Type: Journal Article)
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Chemical References |
- Antimalarials
- Drug Combinations
- Folic Acid Antagonists
- PS 15
- Sulfamethoxazole
- Proguanil
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Topics |
- Animals
- Antimalarials
(blood, pharmacology, therapeutic use)
- Biological Assay
- Drug Combinations
- Drug Resistance, Multiple
- Drug Synergism
- Folic Acid Antagonists
(blood, pharmacology, therapeutic use)
- Malaria, Falciparum
(drug therapy)
- Plasmodium falciparum
(drug effects)
- Proguanil
(analogs & derivatives, blood, pharmacology, therapeutic use)
- Saimiri
- Sulfamethoxazole
(blood, pharmacology, therapeutic use)
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