The activity of PS-15 in combination with sulfamethoxazole.

Abstract

PS-15 is a novel biguanide folate antagonist that is metabolized in vivo to WR99210, a metabolite that is extremely active in vitro against multi-drug resistant strains of Plasmodium falciparum. When PS-15 was administered in combination with sulfamethoxazole to healthy Saimiri sciureus monkeys, the serum antimalarial activity was considerably greater than that observed in monkeys that received PS-15 alone. Further studies should be carried out to determine the value of PS-15/sulfonamide combinations in the treatment of human malaria infections and in preventing the emergence of drug-resistant parasites.

• Authors: A E Yeo, K H Rieckmann
• Journal: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) (Trop Med Parasitol) Vol. 45 Issue 2 Pg. 136-7 (Jun 1994) ISSN: 0177-2392 [Print] Germany
• PMID: 7939165 (Publication Type: Journal Article)

Chemical References

• Antimalarials
• Drug Combinations
• Folic Acid Antagonists
• PS 15
• Sulfamethoxazole
• Proguanil

Topics

• Animals
• Antimalarials (blood, pharmacology, therapeutic use)
• Biological Assay
• Drug Combinations
• Drug Resistance, Multiple
• Drug Synergism
• Folic Acid Antagonists (blood, pharmacology, therapeutic use)
• Malaria, Falciparum (drug therapy)
• Plasmodium falciparum (drug effects)
• Proguanil (analogs & derivatives, blood, pharmacology, therapeutic use)
• Saimiri
• Sulfamethoxazole (blood, pharmacology, therapeutic use)