Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.

1 In anaesthetized rats, bilateral injections of alpha-methylnoradrenaline, noradrenaline or adrenaline into the area of the nucleus tractus solitarii (NTS) of the brain stem caused dose-dependent decreases of systemic arterial blood pressure and heart rate. The effects of alpha-methylnoradrenaline were most pronounced and lasted longest. 2 The cardiovascular effects of alpha-methylnoradrenaline appeared to be restricted to the medio-caudal part of the NTS. 3 Prior administration of the alpha-adrenoceptor blocking agent, phentolamine, reversed the fall in blood pressure and heart rate induced by alpha-methylnoradrenaline into an increase. 4 Systemic administration of atropine combined with vagotomy potentiated the inhibitory effects of alpha-methylnoradrenaline on the cardiovascular system.
AuthorsW De Jong, F P Nijkamp
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 58 Issue 4 Pg. 593-8 (Dec 1976) ISSN: 0007-1188 [Print] ENGLAND
PMID793669 (Publication Type: Journal Article)
Chemical References
  • Atropine
  • Nordefrin
  • Norepinephrine
  • Epinephrine
  • Phentolamine
  • Animals
  • Atropine (pharmacology)
  • Blood Pressure (drug effects)
  • Epinephrine (pharmacology)
  • Heart Rate (drug effects)
  • Injections
  • Male
  • Medulla Oblongata
  • Nordefrin (administration & dosage, pharmacology)
  • Norepinephrine (analogs & derivatives, pharmacology)
  • Phentolamine (pharmacology)
  • Rats
  • Time Factors
  • Vagus Nerve (physiology)

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