Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.

Abstract

1 In anaesthetized rats, bilateral injections of alpha-methylnoradrenaline, noradrenaline or adrenaline into the area of the nucleus tractus solitarii (NTS) of the brain stem caused dose-dependent decreases of systemic arterial blood pressure and heart rate. The effects of alpha-methylnoradrenaline were most pronounced and lasted longest. 2 The cardiovascular effects of alpha-methylnoradrenaline appeared to be restricted to the medio-caudal part of the NTS. 3 Prior administration of the alpha-adrenoceptor blocking agent, phentolamine, reversed the fall in blood pressure and heart rate induced by alpha-methylnoradrenaline into an increase. 4 Systemic administration of atropine combined with vagotomy potentiated the inhibitory effects of alpha-methylnoradrenaline on the cardiovascular system.

• Authors: W De Jong, F P Nijkamp
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 58 Issue 4 Pg. 593-8 (Dec 1976) ISSN: 0007-1188 [Print] England
• PMID: 793669 (Publication Type: Journal Article)

Chemical References

• Atropine
• Nordefrin
• Norepinephrine
• Epinephrine
• Phentolamine

Topics

• Animals
• Atropine (pharmacology)
• Blood Pressure (drug effects)
• Epinephrine (pharmacology)
• Heart Rate (drug effects)
• Injections
• Male
• Medulla Oblongata
• Nordefrin (administration & dosage, pharmacology)
• Norepinephrine (analogs & derivatives, pharmacology)
• Phentolamine (pharmacology)
• Rats
• Time Factors
• Vagus Nerve (physiology)