Abstract |
Chronic inflammation associated with the amyloid plaques may represent an acute phase response in the brain. We quantitated the levels of two inflammatory markers; alpha 1-antichymotrypsin (alpha 1-ACT) and interleukin 1 beta (IL-1 beta) in paired serum and cerebrospinal fluid (CSF) samples from 40 patients with Alzheimer's disease ( AD), 20 patients with Parkinson's disease (PD), and 42 age-matched controls. No differences in serum or CSF levels of either alpha 1-ACT or IL-1 beta were found between the groups. However, some AD patients had increased alpha 1-ACT index, suggesting an intrathecal production of alpha 1-ACT. Although alpha 1-ACT or IL-1 beta might be involved in the pathogenesis of AD, our results show that their measurement in serum or CSF is not valuable to support the clinical diagnosis of AD.
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Authors | T Pirttila, P D Mehta, H Frey, H M Wisniewski |
Journal | Neurobiology of aging
(Neurobiol Aging)
1994 May-Jun
Vol. 15
Issue 3
Pg. 313-7
ISSN: 0197-4580 [Print] United States |
PMID | 7936055
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Albumins
- Biomarkers
- Interleukin-1
- alpha 1-Antichymotrypsin
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Topics |
- Aged
- Albumins
(cerebrospinal fluid, metabolism)
- Alzheimer Disease
(blood, cerebrospinal fluid)
- Biomarkers
(blood, cerebrospinal fluid)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Interleukin-1
(blood, cerebrospinal fluid)
- Parkinson Disease
(blood, cerebrospinal fluid, metabolism)
- alpha 1-Antichymotrypsin
(blood, cerebrospinal fluid)
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