Successful treatment of dendritic keratitis with human leukocyte interferon. A controlled clinical study.

Abstract

There were 40 virologically confirmed cases of dendritic keratitis treated in a randomized double-blind placebo-controlled study. After thermomechanical debridement of the corneal epithelium, the patients received two drops of human leukocyte interferon (HLI) twice daily. The activity was 3 X 10(-6) units/ml. HLI significantly accelerated healing and inhibited virus shedding. It remains to be studied whether HLI will be equally effective in the prophylaxis of late herpes recurrences.

• Authors: R Sundmacher, D Neumann-Haefelin, K Cantell
• Journal: Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology (Albrecht Von Graefes Arch Klin Exp Ophthalmol) Vol. 201 Issue 1 Pg. 39-45 (Nov 18 1976) ISSN: 0065-6100 [Print] Germany
• PMID: 793437 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Interferons

Topics

• Clinical Trials as Topic
• Debridement
• Humans
• Interferons (therapeutic use)
• Keratitis, Dendritic (drug therapy)