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Relation between platinum-DNA adducts and complete remission in adult acute nonlymphocytic leukemia.

Abstract
The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cisplatin in vitro and the amount of platinum bound to DNA was determined using a competitive ELISA procedure and an antibody directed against platinum-modified DNA. Platinum-DNA adduct levels discriminated well between complete remission (CR) and remission failure (RF) patients, treated with mitoxantrone, cytosine arabinoside +/- carboplatin.
AuthorsS G Armstrong, G P Browman, A M Benger, R M Meyer, K L McKay, G Singh
JournalLeukemia research (Leuk Res) Vol. 18 Issue 9 Pg. 659-64 (Sep 1994) ISSN: 0145-2126 [Print] England
PMID7934140 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 1,2-cyclohexanediamine platinum(II)-DNA complex
  • DNA Adducts
  • Organoplatinum Compounds
  • Cytarabine
  • Mitoxantrone
  • Cisplatin
Topics
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bone Marrow (metabolism, pathology)
  • Cisplatin (metabolism)
  • Cytarabine (administration & dosage)
  • DNA Adducts (analysis, metabolism)
  • Female
  • Humans
  • Leukemia, Myeloid, Acute (drug therapy, metabolism, pathology)
  • Male
  • Middle Aged
  • Mitoxantrone (administration & dosage)
  • Organoplatinum Compounds (analysis, metabolism)
  • Predictive Value of Tests
  • Recurrence
  • Remission Induction

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