[Bacteriological and clinical studies of biapenem (L-627) in pediatrics].

Abstract

Bacteriological and clinical studies in the pediatric field have been performed on biapenem (L-627), a newly-developed carbapenem antibiotic, and the following results were obtained. 1. In the pharmacokinetic study, the plasma concentration of L-627 showed dose-dependant change: Cmax was 14.6 micrograms/ml and AUC was 15.4 micrograms.hr/ml with the administration of 6 mg/kg, while Cmax was 49.2 micrograms/ml and AUC was 60.1 micrograms.hr/ml with the administration of 12 mg/kg. After the administration of 6 mg/kg, the urinary concentration reached maximum within 2 hours and the cumulative urinary excretion rate in the first 6 hours was 49.4%. 2. Antibacterial activities of L-627 against 27 strains of clinical isolates were determined. MICs of L-627 against such Gram-positive cocci as Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes were sufficiently low, and those against such Gram-negative rods as Haemophilus influenzae, Escherichia coli and Bordetella pertussis were satisfactory and as low as those of imipenem or ceftazidime. 3. Clinical efficacies of L-627 were evaluated in 36 cases of bacterial infections. The overall efficacy rate was 100%, and excellent responses in 26 cases and good in 10 cases were obtained. As for bacteriological efficacies, all strains except 1 of B. pertussis were eradicated and a high eradication rate of 96.6% was obtained. 4. No side effects were observed in 37 evaluated cases. As abnormal laboratory test results, eosinophilia was noted in 2 cases (5.4%), but they returned to normal values rapidly after the drug was discontinued. From these results, it has been concluded that L-627 is a safe and effective drug to be used in treatment of pediatric infectious diseases.

• Authors: Y Kusumoto, H Akita, Y Sato, S Iwata, Y Takeuchi, T Abe, K Sunakawa, T Yokota
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 47 Issue 7 Pg. 921-31 (Jul 1994) ISSN: 0368-2781 [Print] Japan
• PMID: 7933527 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Thienamycins
• biapenem

Topics

• Adolescent
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy, metabolism, microbiology)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Male
• Pneumonia (drug therapy)
• Thienamycins (pharmacokinetics, therapeutic use)
• Urinary Tract Infections (drug therapy)