Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy.

Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy.
AuthorsY Takeuchi, Y Miyanomae, H Komatsu, Y Oomizono, A Nishimura, S Okano, T Nishiki, T Sawada
JournalJournal of child neurology (J Child Neurol) Vol. 9 Issue 3 Pg. 287-9 (Jul 1994) ISSN: 0883-0738 [Print] UNITED STATES
PMID7930408 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Thyrotropin-Releasing Hormone
  • Age of Onset
  • Child
  • Child, Preschool
  • Electromyography
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Median Nerve
  • Motor Neurons (drug effects)
  • Severity of Illness Index
  • Spinal Muscular Atrophies of Childhood (drug therapy)
  • Thyrotropin-Releasing Hormone (pharmacology, therapeutic use)
  • Tibial Nerve
  • Treatment Outcome

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