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Distribution of VRA09, an ovarian tumor-associated antigen, distinguishing borderline serous tumors.

Abstract
We recently reported the characterization of an antigen designated VRA09, identified by a monoclonal antibody and overexpressed on the surface of vincristine-resistant human ovarian carcinoma cells. In the present study, we analyze the distribution of this antigen in normal and tumor tissues. Its pattern of expression appears to differ from that described for other drug-resistance- and/or tumor-associated antigens. In normal tissues, the antigen has a restricted histological distribution and appears to be localized in mesoderm-derived tissues. In tumor tissues, VRA09 expression was mainly detected in serous ovarian tumors. Indeed, VRA09 is strongly expressed in papillary serous cystadenocarcinomas and their metastases, and more specifically in the basement membranes of serous tumors of borderline malignancy. In contrast, no immunostaining was observed in normal ovarian tissue or benign tumors. The detection of this antigen may help to identify serous ovarian tumors by distinguishing tumors of low malignancy from cystadenocarcinomas.
AuthorsT Voeltzel, P Duvillard, P Ghillani, J Bénard, C Bohuon, D Bellet, J M Bidart
JournalInternational journal of cancer (Int J Cancer) Vol. 59 Issue 2 Pg. 159-64 (Oct 15 1994) ISSN: 0020-7136 [Print] United States
PMID7927912 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Glycoproteins
  • Iodine Radioisotopes
  • ovarian tumor associated antigen
Topics
  • Antibodies, Monoclonal
  • Antigens, Neoplasm (analysis)
  • Diagnosis, Differential
  • Endometrium (chemistry)
  • Epithelium (chemistry, pathology)
  • Female
  • Glycoproteins (chemistry)
  • Humans
  • Immunohistochemistry
  • Iodine Radioisotopes
  • Kidney Glomerulus (chemistry)
  • Lung Neoplasms (chemistry)
  • Membranes (immunology)
  • Ovarian Neoplasms (diagnosis, immunology, pathology)
  • Peritoneum (chemistry, pathology)
  • Radioimmunoassay
  • Trophoblasts (chemistry)

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