Indonesian medicinal plants. VIII. Chemical structures of three new triterpenoids, bruceajavanin A, dihydrobruceajavanin A, and bruceajavanin B, and a new alkaloidal glycoside, bruceacanthinoside, from the stems of Brucea javanica (Simaroubaceae).

Abstract

Three new apotirucallane-type triterpenoids named bruceajavanin A (1) dihydrobruceajavanin A (2) and bruceajavanin B (3), and a novel beta-carboline alkaloidal glycoside named bruceacanthinoside (4) were isolated from the stems of Brucea javanica (Simaroubaceae), a traditional medicine used to treat malaria in the Bengkulu area, Sumatra, Indonesia. Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Bruceajavanin A (1), dihydrobruceajavanin A (2) and bruceacanthinoside (4) were shown to inhibit growth of the cultured malarial parasite Plasmodium falciparum K1 of a chloroquine-resistant strain.

• Authors: I Kitagawa, T Mahmud, P Simanjuntak, K Hori, T Uji, H Shibuya
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 42 Issue 7 Pg. 1416-21 (Jul 1994) ISSN: 0009-2363 [Print] Japan
• PMID: 7923464 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1,2-dihydrobruceajavanin A
• Antimalarials
• Triterpenes
• bruceajavanin A
• bruceajavanin B

Topics

• Animals
• Antimalarials (isolation & purification, pharmacology)
• Humans
• Indonesia
• Magnetic Resonance Spectroscopy
• Plants, Medicinal (chemistry)
• Plasmodium falciparum (drug effects)
• Triterpenes (isolation & purification, pharmacology)