Abstract |
We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdr1. Whereas all-trans retinoic acid had no effect at the concentration of 10(-6) M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 x 10(-6) to 0.57 x 10(-6) M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdr1 gene product does not recognize this retinoic derivative, and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.
|
Authors | C Louvet, S Empereur, D Fagot, E Forgue-Lafitte, E Chastre, A Zimber, J Mester, C Gespach |
Journal | Cancer letters
(Cancer Lett)
Vol. 85
Issue 1
Pg. 83-6
(Sep 30 1994)
ISSN: 0304-3835 [Print] Ireland |
PMID | 7923106
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Morpholines
- Retinoids
- Doxorubicin
- mofarotene
- Fluorouracil
|
Topics |
- Adenocarcinoma
(drug therapy, pathology)
- Antineoplastic Agents
(pharmacology)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Division
(drug effects)
- Colonic Neoplasms
(drug therapy, pathology)
- Doxorubicin
(pharmacology)
- Drug Resistance, Multiple
- Fluorouracil
(pharmacology)
- Humans
- Morpholines
(pharmacology)
- Retinoids
(pharmacology)
- Tumor Cells, Cultured
(drug effects)
|