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The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro.

Abstract
We have examined the antiproliferative effects of the arotinoid Ro 40-8757 in 3 drug-resistant human adenocarcinoma cell lines: the colonic cells HT29-5FU and CaCo2, and the mammary cells MCF-7mdr1. Whereas all-trans retinoic acid had no effect at the concentration of 10(-6) M, Ro 40-8757 was found to exert a high antiproliferative action with similar inhibitory potency (IC50) in drug-resistant and parental cell lines (range, 0.06 x 10(-6) to 0.57 x 10(-6) M). We conclude that: (1) thymidylate synthase is not involved in the mechanism of action of Ro 40-8757; (2) the mdr1 gene product does not recognize this retinoic derivative, and (3) Ro 40-8757, alone or in combinations with other cytotoxic drugs, can be very useful in patients with progressive disease after conventional chemotherapy.
AuthorsC Louvet, S Empereur, D Fagot, E Forgue-Lafitte, E Chastre, A Zimber, J Mester, C Gespach
JournalCancer letters (Cancer Lett) Vol. 85 Issue 1 Pg. 83-6 (Sep 30 1994) ISSN: 0304-3835 [Print] Ireland
PMID7923106 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Morpholines
  • Retinoids
  • Doxorubicin
  • mofarotene
  • Fluorouracil
Topics
  • Adenocarcinoma (drug therapy, pathology)
  • Antineoplastic Agents (pharmacology)
  • Breast Neoplasms (drug therapy, pathology)
  • Cell Division (drug effects)
  • Colonic Neoplasms (drug therapy, pathology)
  • Doxorubicin (pharmacology)
  • Drug Resistance, Multiple
  • Fluorouracil (pharmacology)
  • Humans
  • Morpholines (pharmacology)
  • Retinoids (pharmacology)
  • Tumor Cells, Cultured (drug effects)

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